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Panama Canal cruise season runs from October to April is the most popular season for these itineraries.. The best time to go is after the rainy season ends in November. Experience the Panama Canal, and the port cities of Central America including Puntarenas, Cartagena, Puerto Limon, San Blas Islands, and Roatan. Some lines operate Central America/Panama Canal cruises throughout the year, but October through April is the most popular season for these itineraries. Many Panama Canal cruises ... View more

Cruise Deals in Panama Canal Cruises
No cruise deal for this region!